Sachie is going to Hope Peaks ten years after the Tragedy but it looks like a new Tragedy is about to start. 16 new students are trapped in a Despair Hotel with the only way out is to kill their fellow classmates. Will history repeat itself?

Despair Disease has affected three patients, Ibuki, Akane, and Hajime. Most assumed that someone would get killed soon enough, and they could all go back to their cottages. Its been weeks since the disease broke out, and everyone's condition is declining. Will hope prevail, or will despair?